The thing you have to consider though for the question is whether the ailment begins to afflict you from birth or if it's something that suddenly happens to you at some point in your life. If it's the latter, I think I could handle not being able to see, although I wouldn't like it. I'd be used enough to my surroundings that I think I'd be able to function without seeing. And they have service dogs and guide dogs too which are helpful to people with these handicaps (trust me I've had a service dog though I just use a wheelchair). But either way, whenever I became deaf, I still couldn't imagine never hearing the music of the Beatles or other bands I love, or never hearing my family tell me they love me. I know there are other ways to express it, but being able to hear it is priceless.